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A comparison of 12 AI agent frameworks based on production experience, ranking them by reliability and use case fit. LangGraph, CrewAI, and OpenAI Agents SDK top the list for production readiness, with detailed breakdowns of strengths, limitations, and real-world debugging scenarios. Covers specialized tools like AutoGen for multi-agent debates, Pydantic AI for type safety, and domain-specific options like AWS Bedrock for enterprise and Pipecat for voice. Highlights persistent gaps in evaluation tooling, memory management, and cost tracking across all frameworks.