A type of nanoparticle called a metal organic framework (MOF) could be used to deliver vaccines and act as an adjuvant. MIT researchers find these particles provoke a strong immune response by activating the innate immune system through cell proteins called toll-like receptors.

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Scientists at MIT have demonstrated that metal organic frameworks (MOFs) can provoke a strong immune response and act as adjuvants in vaccines. The study focused on a MOF called ZIF-8 and showed that it could successfully deliver part of the SARS-CoV-2 spike protein. Further research is needed to evaluate the safety and scalability of MOFs as vaccine carriers.

MIT scientists use a new type of nanoparticle to make vaccines more powerful