YouTube used the Vitess MySQL combination to support 2.49 billion users, overcoming scalability issues. Vitess provides an abstraction layer on top of MySQL for simplicity and scalability, using components like VTGate, VTTablet, and a key-value database.

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1. Sharding:2. Performance:3. Protection:1. Interacting with Database:2. Routing SQL Queries:3. State Information:TL;DR:References1 Comment
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