Istio 1.28.1 is a patch release that addresses multiple bug fixes and security vulnerabilities. Key improvements include support for multiple targetPorts in InferencePool, fixes for ambient mode issues with ServiceEntry resources and multi-network connections, resolution of EDS endpoint configuration problems in waypoints and gateways, and corrections for nftables rules and DNS name table creation. The release also implements security updates detailed in ISTIO-SECURITY-2025-003.

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